Razaxaban hydrochloride

Description: Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity. Target: Others. Smiles: Cl.O=C(NC1=CC=C(C=C1F)N2C=CN=C2CN(C)C)C3=CC(=NN3C=4C=CC=5ON=C(N)C5C4)C(F)(F)F. References: Quan ML, et al. Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. J Med Chem. 2005 Mar 24,48(6):1729-44.