Rapamycin-d3

Rapamycin-d3 is intended for use as an internal standard for the quantification of rapamycin (Cay-13346) by GC- or LC-MS. Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml. It also induces autophagy in a variety of cell types. Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM. Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.Formal Name: 7-O-demethyl-7-O-(methyl-d3)-rapamycin. CAS Number: 392711-19-2. Synonyms: Sirolimus-d3. Molecular Formula: C51H76D3NO13. Formula Weight: 917.2. Purity: >98% deuterated forms (d1-d3). Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: 5 mg/ml, DMSO: 25 mg/ml, Ethanol: 50 mg/ml, Methanol: 25 mg/ml. lambdamax: 268, 278, 289 nm. SMILES: O=C(C(N1[C@H](C(O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@@H]3C)=O)=O)=O)CCCC1)=O)[C@]4(O)O[C@H](C[C@H](OC([2H])([2H])[2H])/C(C)=C/C=C/C=C/[C@@H](C)C3)CC[C@H]4C. InChi Code: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1/i8D3. InChi Key: QFJCIRLUMZQUOT-PGDKAFJSSA-N.