Raltegravir (potassium salt)

Raltegravir is an orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay). It inhibits the spread of HIV-1IIIb infection in MT-4 cell culture with 95% cell culture inhibitory concentration (CIC95) values of 19 and 31 nM in medium containing 10% heat-inactivated fetal bovine serum (FBS) or 50% normal human serum, respectively. Formulations containing raltegravir have been used in combination therapy in the treatment of HIV-1 infection.Formal Name: N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide, monopotassium salt. CAS Number: 871038-72-1. Synonyms: MK-0518. Molecular Formula: C20H20FN6O5 . K. Formula Weight: 482.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 210, 312 nm. SMILES: O=C(NC(C)(C)C1=NC(C(NCC2=CC=C(F)C=C2)=O)=C([O-])C(N1C)=O)C3=NN=C(C)O3.[K+]. InChi Code: InChI=1S/C20H21FN6O5.K/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11,/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30),/q,+1/p-1. InChi Key: IFUKBHBISRAZTF-UHFFFAOYSA-M.