Raloxifene 4'-Glucuronide

Raloxifene 4'-glucuronide is a metabolite of the selective estrogen receptor modulator raloxifene (Cay-10011620). It is formed from raloxifene via the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A8, and UGT1A10. It binds to the estrogen receptor with an IC50 value of 370 nM. Raloxifene 4'-glucuronide inhibits the voltage-gated potassium channel Kv4.3 by 6.2 and 20.1% when used at concentrations of 10 and 30 µM, respectively.Formal Name: 4-[6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl, beta-D-glucopyranosiduronic acid. CAS Number: 182507-22-8. Synonyms: Ral-4'-Gluc. Molecular Formula: C34H35NO10S. Formula Weight: 649.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: OC1=CC=C(C(C(C2=CC=C(OCCN3CCCCC3)C=C2)=O)=C(C4=CC=C(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)C=C4)S6)C6=C1. InChi Code: InChI=1S/C34H35NO10S/c36-21-8-13-24-25(18-21)46-32(20-6-11-23(12-7-20)44-34-30(40)28(38)29(39)31(45-34)33(41)42)26(24)27(37)19-4-9-22(10-5-19)43-17-16-35-14-2-1-3-15-35/h4-13,18,28-31,34,36,38-40H,1-3,14-17H2,(H,41,42)/t28-,29-,30+,31-,34+/m0/s1. InChi Key: VHXYPEXOSLGZKH-WKRHDJAJSA-N. Bureau of Industry & Security: Regulated.