Ractopamine (hydrochloride)

Ractopamine is a trace amine-associated receptor 1 (TAAR1) agonist. It increases chloride conductance in X. laevis oocytes expressing the human cystic fibrosis transmembrane conductance regulator (CFTR) and mouse TAAR1 (EC50 = 16 µM), an effect that can be blocked by the TAAR1 antagonist EPPTB (Cay-34330). It selectively induces chloride conductance in TAAR1- and CFTR-expressing oocytes over those expressing the human beta2-adrenergic receptor (beta2-AR) and CFTR at 36 µM. However, it is also considered a beta2-AR agonist that binds to beta2-ARs (Ki = 0.18 µM for the recombinant human receptor expressed in Sf9 cells) and induces relaxation of isolated guinea pig trachea with an EC50 value of 9.1 nM. Formulations containing ractopamine have been used as food additives in livestock to increase weight gain and leanness and improve feed efficiency.Formal Name: 4-hydroxy-alpha-[[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]-benzenemethanol, monohydrochloride. CAS Number: 90274-24-1. Synonyms: LY031537. Molecular Formula: C18H23NO3 . HCl. Formula Weight: 337.8. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 226 nm. SMILES: OC1=CC=C(C(O)CNC(C)CCC2=CC=C(O)C=C2)C=C1.Cl. InChi Code: InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-8-16(20)9-5-14)19-12-18(22)15-6-10-17(21)11-7-15,/h4-11,13,18-22H,2-3,12H2,1H3,1H. InChi Key: JHGSLSLUFMZUMK-UHFFFAOYSA-N.