Rabeprazole-d4 (sodium salt)

Rabeprazole-d4 is intended for use as an internal standard for the quantification of rabeprazole (Cay-14939) by GC- or LC-MS. Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM). It can be activated more rapidly and over a greater pH range than other proton pump inhibitors such as omeprazole (Cay-14880), lansoprazole (Cay-13627), and pantoprazole (Cay-21345). Rabeprazole (30 mg/kg) inhibits gastric acid secretion in pylorus-ligated rats and a rat model of gastric fistula. It also inhibits the growth of several strains of H. pylori in vitro (MIC50s = 1.57-3.13 µg/mL). Formulations containing rabeprazole have been used in the treatment of ulcers, pathological hypersecretory conditions, and gastroesophageal reflux disease (GERD).Formal Name: 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-4,5,6,7-d4, monosodium salt. Molecular Formula: C18H16D4N3O3S . Na. Formula Weight: 385.4. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CC1=C(CS(C2=NC3=C(C([2H])=C([2H])C([2H])=C3[2H])[N-]2)=O)N=CC=C1OCCCOC.[Na+]. InChi Code: InChI=1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18,/h3-4,6-9H,5,10-12H2,1-2H3,/q-1,+1/i3D,4D,6D,7D,. InChi Key: KRCQSTCYZUOBHN-SWSVCJOSSA-N.