RA-2

Description: RA-2 is a pan-negative-gating modulator of KCa2/3 channels that acts by inhibiting EDH-type relaxation in coronary arteries. Target: Others. Smiles: C(OCC1=CC(COC(=O)C2=CC(F)=C(O)C=C2)=CC=C1)(=O)C3=CC(F)=C(O)C=C3. References: Uttley L, Bermejo I, Ren S, Martyn-St James M, Wong R, Scott DL, Young A, Stevenson M. Tofacitinib for Treating Rheumatoid Arthritis After the Failure of Disease-Modifying Anti-rheumatic Drugs: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics. 2018 Mar 15. doi: 10.1007/s40273-018-0639-0. [Epub ahead of print] Review. PubMed PMID: 29546668.