(R)-Pramipexole (hydrochloride)

Pramipexole (Cay-11981) is an agonist of dopamine receptors that has applications in Parkinson's disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist. For this reason, it can be used as a negative control for the (S) form in the study of dopamine receptors. Both isoforms are antioxidants that target mitochondria to prevent apoptosis. This cytoprotective effect of (R)-pramipexole, without dopaminergic side effects, suggests utility in amyotrophic lateral sclerosis.Formal Name: 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride. CAS Number: 104632-27-1. Synonyms: Dexpramipexole, KNS 760704, (+)-Pramipexole, SND 919CL2X. Molecular Formula: C10H17N3S . 2HCl. Formula Weight: 284.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 219, 264 nm. SMILES: CCCN[C@@H]1CCC(N=C(N)S2)=C2C1.Cl.Cl. InChi Code: InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8,,/h7,12H,2-6H2,1H3,(H2,11,13),2*1H/t7-,,/m1../s1. InChi Key: QMNWXHSYPXQFSK-XCUBXKJBSA-N.