(R)-KT109

Description: (R)-KT109 is the (R) isomer of the diacylglycerol lipase beta (DAGLbeta) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLbeta (IC50 = 0.79 nM) and of DAGLalpha-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLbeta, DAGLalpha, and ABHD6 than (S)-KT109 . Target: Others. Smiles: C(=O)(N1[C@@H](CC2=CC=CC=C2)CCCC1)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC=C5