(R)-(+)-BAY-K-8644

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 µM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(-)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.Formal Name: (4R)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester. CAS Number: 98791-67-4. Synonyms: NI 105, R 4407. Molecular Formula: C16H15F3N2O4. Formula Weight: 356.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml. lambdamax: 237, 273, 406 nm. SMILES: O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@@H]1C2=CC=CC=C2C(F)(F)F. InChi Code: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m1/s1. InChi Key: ZFLWDHHVRRZMEI-CYBMUJFWSA-N.