Quinolinic Acid

Quinolinic acid is an active metabolite of tryptophan (Cay-29600, Cay-31210) and an NMDA receptor agonist. It is formed from tryptophan via the kynurenine pathway. Quinolinic acid (100 µM) induces lipid peroxidation in rat brain synaptosomes, an effect that can be reversed by the NMDA receptor antagonist 2-amino-5-phosphonovaleric acid. It decreases the viability of primary rat neurons when used at a concentration of 25 µM. Intracerebroventricular administration of quinolinic acid (1 µg/animal) induces convulsions in mice. Increased plasma levels of quinolinic acid negatively correlate with Brief Neurocognitive Assessment (BNA) scores in patients with schizophrenia.Formal Name: 2,3-pyridinedicarboxylic acid. CAS Number: 89-00-9. Synonyms: NSC 13127, NSC 18836, NSC 403247. Molecular Formula: C7H5NO4. Formula Weight: 167.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 16 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 216, 264 nm. SMILES: O=C(O)C1=CC=CN=C1C(O)=O. InChi Code: InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12). InChi Key: GJAWHXHKYYXBSV-UHFFFAOYSA-N. Origin: Synthetic.