Quinidine-d3

Quinidine-d3 is intended for use as an internal standard for the quantification of quinidine (Cay-20356) by GC- or LC-MS. Quinidine is a stereoisomer of the antimalarial agent quinine (Cay-23958) and a class Ia antiarrhythmic agent. Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner. It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes. Quinidine inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM. It induces QT prolongation in dogs. Quinidine also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells). Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.Formal Name: 6'-(methoxy-d3)-cinchonan-9S-ol. CAS Number: 1267657-68-0. Synonyms: (+)-Quinidine-d3, beta-Quinidine-d3. Molecular Formula: C20H21D3N2O2. Formula Weight: 327.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly, heated. SMILES: C=C[C@@H](C[N@@]1CC2)[C@@H]2C[C@]1([H])[C@@H](O)C3=CC=NC4=CC=C(OC([2H])([2H])[2H])C=C43. InChi Code: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1/i2D3. InChi Key: LOUPRKONTZGTKE-QMROFPFZSA-N.