Quinidine

Quinidine is a stereoisomer of the antimalarial agent quinine (Cay-23958) and a class Ia antiarrhythmic agent. Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner. It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes. It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM. Quinidine induces QT prolongation in dogs. It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells). Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.Formal Name: 6'-methoxy-cinchonan-9S-ol. CAS Number: 56-54-2. Synonyms: (+)-Quinidine, beta-Quinidine. Molecular Formula: C20H24N2O2. Formula Weight: 324.4. Purity: >95% (may contain up to 15% hydroquinidine). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 232, 280, 334 nm. SMILES: COC1=CC=C2C(C([C@H](O)[C@@]3([H])C[C@H]4[C@@H](C=C)C[N@@]3CC4)=CC=N2)=C1. InChi Code: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1. InChi Key: LOUPRKONTZGTKE-LHHVKLHASA-N.