Quercetin 3-O-glucuronide

Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John's wort) that inhibits the alpha2c adrenergic receptor (Ki = 4,060 nM in halpha2c preparations).{33869,33870, 33974} Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically. It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).Formal Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-ylbeta-D-glucopyranosiduronic acid. CAS Number: 22688-79-5. Synonyms: Miquelianin, Quercetin 3-O-beta-D-glucuronide. Molecular Formula: C21H18O13. Formula Weight: 478.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 258, 363 nm. SMILES: OC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O2)=C(C3=CC=C(O)C(O)=C3)O4)=O)C4=C1. InChi Code: InChI=1S/C21H18O13/c22-7-4-10(25)12-11(5-7)32-17(6-1-2-8(23)9(24)3-6)18(13(12)26)33-21-16(29)14(27)15(28)19(34-21)20(30)31/h1-5,14-16,19,21-25,27-29H,(H,30,31)/t14-,15-,16+,19-,21+/m0/s1. InChi Key: DUBCCGAQYVUYEU-ZUGPOPFOSA-N.