Pyrrophenone

Pyrrophenone
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
TGM-T37331-500ug 500 µg -

7 - 10 Werktage*

296,00 €
TGM-T37331-1mg 1 mg

7 - 10 Werktage*

589,00 €
TGM-T37331-5mg 5 mg

7 - 10 Werktage*

2.272,00 €
TGM-T37331-10mg 10 mg

7 - 10 Werktage*

4.340,00 €
 
Description: The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2... mehr
Produktinformationen "Pyrrophenone"
Description: The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2alpha with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as pyrrophenone inhibits the secretory type IB and IIA PLA2s with more than a hundred-fold less potency. Pyrrophenone has also been shown to inhibit calcium ionophore (A23187)-stimulated AA release from monocytic cells, interleukin-1-induced PGE2 synthesis in mesangial cells, and the production of PGE2, LTs, and platelet-activating factor by human neutrophils, always with maximal inhibition at concentrations below 1 µM. Target: Others. Smiles: Fc1ccc(C(=O)c2ccccc2C(=O)N2C[C@@H](C[C@H]2CNC(=O)c2ccc(\C=C3/SC(=O)NC3=O)cc2)SC(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)c1
Hersteller: TargetMol
Hersteller-Nr: T37331

Eigenschaften

MW: 849.97 D
Formel: C49H37F2N3O5S2

Datenbank Information

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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