PX-478

Description: PX-478 is a HIF-1alpha inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic beta-cell function in diabetes mellitus and is used in type 2 diabetes mellitus research. Target: HIF, Autophagy, HIF/HIF Prolyl-Hydroxylase. Smiles: Cl.Cl.N[C@@H](Cc1ccc(cc1)[N+]([O-])(CCCl)CCCl)C(O)=O. References: Koh MY, et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Mol Cancer Ther. 2008 Jan,7(1):90-100.