PS-210

PS-210 is an activator of phosphoinositide-dependent protein kinase 1 (PDK1) that increases its thermal stability. It is selective for PDK-1 over a panel of 120 kinases at 10 µM. PS-210 (2 µM) increases the activity of wild-type PDK1 but not PDK1 with a mutation in the PIF-binding pocket.Formal Name: 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid. CAS Number: 1221962-86-2. Molecular Formula: C19H15F3O5. Formula Weight: 380.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 235 nm. SMILES: FC(F)(F)C1=CC=C(C(CC(C2=CC=CC=C2)C(C(O)=O)C(O)=O)=O)C=C1. InChi Code: InChI=1S/C19H15F3O5/c20-19(21,22)13-8-6-12(7-9-13)15(23)10-14(11-4-2-1-3-5-11)16(17(24)25)18(26)27/h1-9,14,16H,10H2,(H,24,25)(H,26,27). InChi Key: MLJPLHGJBUWCBA-UHFFFAOYSA-N.