Proteasome inhibitor IX

Description: Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 µM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 µM). Target: Proteasome. Smiles: CN1C\C(=C\c2ccc(cc2)B(O)O)C(=O)\C(C1)=C/c1ccc(cc1)B(O)O. References: Encouse B Golden, et al. Green Tea Polyphenols Block the Anticancer Effects of Bortezomib and Other Boronic Acid-Based Proteasome Inhibitors. Blood. 2009 Jun 4,113(23):5927-37.