PROTAC CRBN Degrader-1

PROTAC CRBN degrader-1 is a proteolysis-targeting chimera (PROTAC) that contains VHL ligand 1 (Cay-21591) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877). It induces degradation of CRBN in HeLa cells with a half-maximal degradation concentration (DC50) value of 200 nM.Formal Name: N1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide. CAS Number: 2358775-70-7. Synonyms: PROTAC Cereblon Degrader-1, Proteolysis-targeting Chimera Cereblon Degrader-1, Proteolysis-targeting Chimera CRBN Degrader-1. Molecular Formula: C53H72N8O13S. Formula Weight: 1061.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: CC(C)(C)[C@@H](C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)O)=O)NC(COCCCCCOCCOCCCCCOCC(NCCNC4=C5C(C(N(C5=O)C6CCC(NC6=O)=O)=O)=CC=C4)=O)=O. InChi Code: InChI=1S/C53H72N8O13S/c1-34-46(75-33-57-34)36-16-14-35(15-17-36)29-56-48(66)41-28-37(62)30-60(41)52(70)47(53(2,3)4)58-44(65)32-74-25-10-6-8-23-72-27-26-71-22-7-5-9-24-73-31-43(64)55-21-20-54-39-13-11-12-38-45(39)51(69)61(50(38)68)40-18-19-42(63)59-49(40)67/h11-17,33,37,40-41,47,54,62H,5-10,18-32H2,1-4H3,(H,55,64)(H,56,66)(H,58,65)(H,59,63,67)/t37-,40?,41+,47-/m1/s1. InChi Key: PEZCAXDTKNFUCR-CTMFSBKBSA-N.