Propylthiouracil

Propylthiouracil (PTU) is a thioamide antithyroid agent. It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 µM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3'-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds. Formulations containing propylthiouracil have been used in the treatment of Graves' disease and hyperthyroidism.Formal Name: 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone. CAS Number: 51-52-5. Synonyms: NSC 6498, NSC 70461, 6-n-Propylthiouracil, PTU. Molecular Formula: C7H10N2OS. Formula Weight: 170.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.50 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml. lambdamax: 214, 275 nm. SMILES: S=C1NC(C=C(CCC)N1)=O. InChi Code: InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11). InChi Key: KNAHARQHSZJURB-UHFFFAOYSA-N.