Propantheline (bromide)

Propantheline is an anticholinergic agent. It inhibits contraction of isolated guinea pig ileum induced by acetylcholine (Cay-23829) and reduces intensity of vagal-stimulated gastric contractions in rats. Propantheline (5 mg/kg, s.c.) increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats. It also inhibits basal and pentagastrin-, but not histamine-, stimulated gastric secretion in a rhesus monkey model of chronic gastric fistula. Formulations containing propantheline have been used to treat stomach and intestinal spasms associated with irritable bowel syndrome.Formal Name: N-methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl]-2-propanaminium, monobromide. CAS Number: 50-34-0. Synonyms: SC-3171. Molecular Formula: C23H30NO3. Br. Formula Weight: 448.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(OCC[N+](C(C)C)(C)C(C)C)C1C2=C(C=CC=C2)OC3=CC=CC=C31.[Br-]. InChi Code: InChI=1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22,/h6-13,16-17,22H,14-15H2,1-5H3,1H/q+1,/p-1. InChi Key: XLBIBBZXLMYSFF-UHFFFAOYSA-M.