Promethazine (hydrochloride)

Promethazine is a first-generation histamine H1 receptor antagonist (Ki = 0.98 nM for the human receptor). It is selective for histamine H1 over H3 and H4 receptors (Kis = >100 and 77.6 µM, respectively, for the human receptors). Promethazine also binds muscarinic acetylcholine receptors (mAChRs, Ki = 22 nM). It inhibits histamine-induced paw edema and acetic acid-induced writhing in mice (ED50s = 5.9 and 11.8 mg/kg, respectively). Promethazine (32 mg/kg) decreases the number of motion-induced vomiting episodes in S. murinus.Formal Name: N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine, monohydrochloride. CAS Number: 58-33-3. Synonyms: NSC 231688. Molecular Formula: C17H20N2S . HCl. Formula Weight: 320.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 252 nm. SMILES: CC(N(C)C)CN1C2=C(C=CC=C2)SC3=CC=CC=C31.Cl. InChi Code: InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19,/h4-11,13H,12H2,1-3H3,1H. InChi Key: XXPDBLUZJRXNNZ-UHFFFAOYSA-N.