Prochlorperazine (maleate)

Prochlorperazine (maleate)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay20742-50 50 mg -

6 - 10 Werktage*

43,00 €
Cay20742-100 100 mg -

6 - 10 Werktage*

82,00 €
Cay20742-250 250 mg -

6 - 10 Werktage*

187,00 €
Cay20742-500 500 mg -

6 - 10 Werktage*

325,00 €
 
Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat... mehr
Produktinformationen "Prochlorperazine (maleate)"
Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively. It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM). Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor. It also inhibits emesis induced by apomorphine (Cay-16094) in dogs (ED50 = 0.34 mg/kg). Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.Formal Name: 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine, dimaleate. CAS Number: 84-02-6. Molecular Formula: C20H24ClN3S . 2C4H4O4. Formula Weight: 606.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 258, 312 nm. SMILES: CN1CCN(CCCN2C(C=CC=C3)=C3SC4=C2C=C(Cl)C=C4)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O. InChi Code: InChI=1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24,2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3,2*1-2H,(H,5,6)(H,7,8)/b,2*2-1-. InChi Key: DSKIOWHQLUWFLG-SPIKMXEPSA-N.
Schlagworte: 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine, dimaleate
Hersteller: Cayman Chemical
Hersteller-Nr: 20742

Eigenschaften

Anwendung: Dopamine D2 receptor antagonist
MW: 606.1 D
Formel: C20H24ClN3S . 2C4H4O4
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 84-02-6| Passende Produkte
KEGG ID : K04145 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302, H312, H332
P-Sätze: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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