PRLX-93936

PRLX-93936 is an analog of erastin (Cay-17754) that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 µM in a cell-based reporter assay). PRLX-93936 (1 µM) also inhibits hypoxia-induced increases in HIF-1alpha expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM. PRLX-93936 inhibits tumor growth in PANC-1 and HT-1080 xenograft models when administered at a dose of 50 mg/kg and induces tumor regression when administered at a dose of 100 mg/kg.Formal Name: 3-(2-ethoxyphenyl)-2-(1-piperazinylmethyl)-4(3H)-quinazolinone. CAS Number: 903499-49-0. Molecular Formula: C21H24N4O2. Formula Weight: 364.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: CCOC1=CC=CC=C1N2C(CN3CCNCC3)=NC(C=CC=C4)=C4C2=O. InChi Code: InChI=1S/C21H24N4O2/c1-2-27-19-10-6-5-9-18(19)25-20(15-24-13-11-22-12-14-24)23-17-8-4-3-7-16(17)21(25)26/h3-10,22H,2,11-15H2,1H3. InChi Key: OBWOSMGNXYUDFB-UHFFFAOYSA-N.