Prinomastat hydrochloride

Description: Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity. Target: MMP. Smiles: S(=O)(=O)(N1[C@@H](C(NO)=O)C(C)(C)SCC1)C2=CC=C(OC=3C=CN=CC3)C=C2.Cl. References: Sørensen MD, et al. Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity. Bioorg Med Chem. 2003 Dec 1,11(24):5461-84.