PQR620

PQR620 is an inhibitor of mTOR (Ki = 10.8 nM). It is selective for mTOR over PI3K p110alpha (Ki = 4.2 µM) and a panel of 456 other kinases at 10 µM. PQR620 has antiproliferative activity against a panel of 66 cancer cell lines (mean IC50 = 919 nM). It induces cell cycle arrest at the G1 phase in A2058 melanoma and SKOV3 ovarian cancer cells when used at a concentration of 5 µM. In vivo, PQR620 (100 mg/kg per day) decreases the number of seizures per week in a Tsc1GFAP conditional knockout mouse model of epilepsy to a similar extent as PQR530 (Cay-28563).Formal Name: 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine. CAS Number: 1927857-56-4. Molecular Formula: C21H25F2N7O2. Formula Weight: 445.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: NC1=NC=C(C2=NC(N3C4COCC3CC4)=NC(N5[C@H]6COC[C@@H]5CC6)=N2)C(C(F)F)=C1. InChi Code: InChI=1S/C21H25F2N7O2/c22-18(23)15-5-17(24)25-6-16(15)19-26-20(29-11-1-2-12(29)8-31-7-11)28-21(27-19)30-13-3-4-14(30)10-32-9-13/h5-6,11-14,18H,1-4,7-10H2,(H2,24,25)/t11-,12+,13?,14?. InChi Key: UGDKPWVVBKHRDK-VTXSZYRJSA-N.