Porcupine-IN-1

Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays). It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 µM, indicating inhibition of porcupine, an enzyme that catalyzes palmitoylation of Wnt proteins.Formal Name: N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-9H-carbazole-2-carboxamide. CAS Number: 2036044-77-4. Synonyms: PORCN-IN-1. Molecular Formula: C25H19FN4O. Formula Weight: 410.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: slightly soluble. lambdamax: 250, 304 nm. SMILES: CC1=NC=CC(C2=NC=C(CNC(C3=CC(NC4=C5C=CC=C4)=C5C=C3)=O)C=C2F)=C1. InChi Code: InChI=1S/C25H19FN4O/c1-15-10-17(8-9-27-15)24-21(26)11-16(13-28-24)14-29-25(31)18-6-7-20-19-4-2-3-5-22(19)30-23(20)12-18/h2-13,30H,14H2,1H3,(H,29,31). InChi Key: GOMFFTZBKYVUOE-UHFFFAOYSA-N.