POM 1

POM 1 is a polyoxometalate that inhibits ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) 1 and 3 with Ki values of 2.58 and 3.26 µM, respectively. It demonstrates 10-fold lower inhibitory activity for NTPDase 2 (Ki = 28.8 µM) and does not inhibit P2Y12 receptors (Ki > 10 µM). Inhibition of ecto-NTPDases that are capable of hydrolyzing nucleoside tri- and diphosphates (i.e., ATP, ADP, UTP, or UDP) can result in a potentiation of purinergic signaling due to an increase in the extracellular nucleotide concentrations. This subtype-selective NTPase inhibitor has been used to investigate the mechanisms of purinergic signaling.Formal Name: tungstate (W12(OH)2O386-), hexasodium salt, monohydrate. CAS Number: 314075-43-9. Synonyms: Sodium Metatungstate, Sodium Polyoxotungstate. Molecular Formula: H2O40W12 . H2O . 6Na. Formula Weight: 3004.0. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.12 mg/ml, DMSO: 0.16 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: O=[W+4]([O-2]1)([O-2][W+4]([OH-]2[W+4]34([O-2]5)([O-2]6)=O)([O-2]3)([O-2]7)([O-2]8)=O)([O-2][W+4]9%10([O-2][W+4]%11%12([O-2]%13)([O-2]%14)=O)([O-2][W+4]%15%16%14([O-2]%17)=O)=O)([O-2][W+4]8([O-2]%15[W+4]%18%176([O-2]%19)=O)([O-2]%18)([O-2]%16)=O)[OH-]9[W+4]1([O-2][W+4]([O-2]%11[W+4]%20%135%19=O)([O-2]%20)([O-2]%12)([O-2]%21)=O)([O-2][W+4]27%21([O-2]4)=O)([O-2]%10)=O.[Na+].O.[Na+].[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/6Na.3H2O.38O.12W/h,,,,,,3*1H2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,/q6*+1,,,,,,,,,,,,,,,,26*-2,12*+4/p-2. InChi Key: VBYQPULVKQWCQY-UHFFFAOYSA-L.