PNU-282987 free base

Description: PNU-282987 (free base) is a potent agonist of alpha7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 154 nM and a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. It can be used for central and peripheral nervous system studies[1]. Target: 5-HT Receptor, AChR. Smiles: Clc1ccc(cc1)C(=O)N[C@H]1CN2CCC1CC2. References: Bodnar AL,et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24,48(4):905-8.