PKUMDL-LC-101-D04

Description: PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 µM in a cell-free assay, and at a concentration of 61 µM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 µM) reduced cholesterol peroxide-induced MEF death. Target: GPX. Smiles: Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1. References: Li C, et al. Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 2019,62(1):266-275.