PKG Inhibitor

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 µM). This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B. PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.Formal Name: L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid. CAS Number: 82801-73-8. Synonyms: Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid, Protein Kinase G Inhibitor. Molecular Formula: C38H74N18O10. Formula Weight: 943.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 15 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CCCNC(N)=N)=O)CCCCN)N[C@@H](CCC(O)=O)C(O)=O. InChi Code: InChI=1S/C38H74N18O10/c1-21(29(59)52-26(13-8-20-50-38(46)47)33(63)54-24(11-3-5-17-40)34(64)56-27(35(65)66)14-15-28(57)58)51-31(61)25(12-7-19-49-37(44)45)55-32(62)23(10-2-4-16-39)53-30(60)22(41)9-6-18-48-36(42)43/h21-27H,2-20,39-41H2,1H3,(H,51,61)(H,5. InChi Key: OUKSKNTVYYVIMZ-DUJSLOSMSA-N.