Pixantrone (maleate)

Pixantrone is a DNA topoisomerase II inhibitor. It induces SV40 DNA cleavage in the presence of mouse topoisomerase II and induces DNA single-strand breaks in NCI H187 cells in a concentration-dependent manner. Pixantrone is cytotoxic to L1210 leukemia cells as well as doxorubicin-sensitive and -resistant LoVo colon adenocarcinoma cells (IC50 = 0.01, 0.24, and 7.2 µg/ml, respectively). It decreases disease severity in a rat model of myasthenia gravis induced by immunization with the T. californica acetylcholine receptor (AChR) when administered at a dose of 8.12 mg/kg once per week for six weeks. Formulations containing pixantrone have been used in the treatment of non-Hodgkin B cell lymphoma.Formal Name: 6,9-bis[(2-aminoethyl)amino]-benz[g]isoquinoline-5,10-dione, dimaleate. CAS Number: 144675-97-8. Synonyms: BBR 2778. Molecular Formula: C17H19N5O2 . 2C4H4O4. Formula Weight: 557.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml. lambdamax: 214, 324, 513 nm. SMILES: NCCNC1=C2C(C(C(C=CN=C3)=C3C2=O)=O)=C(NCCN)C=C1.OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C17H19N5O2.2C4H4O4/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24,2*5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2,2*1-2H,(H,5,6)(H,7,8)/b,2*2-1-. InChi Key: SVAGFBGXEWPNJC-SPIKMXEPSA-N.