Pirmenol

Pirmenol is a class I antiarrhythmic agent. It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM. Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.Formal Name: rel-alpha-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-alpha-phenyl-2-pyridinemethanol. CAS Number: 68252-19-7. Synonyms: (±)-Pirmenol. Molecular Formula: C22H30N2O. Formula Weight: 338.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2mg/mL, DMSO: 5mg/mL, Ethanol: 10mg/mL, Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL. SMILES: OC(C1=NC=CC=C1)(C2=CC=CC=C2)CCCN3[C@H](C)CCC[C@@H]3C. InChi Code: InChI=1S/C22H30N2O/c1-18-10-8-11-19(2)24(18)17-9-15-22(25,20-12-4-3-5-13-20)21-14-6-7-16-23-21/h3-7,12-14,16,18-19,25H,8-11,15,17H2,1-2H3/t18-,19+,22?. InChi Key: APUDBKTWDCXQJA-QIDMFYOTSA-N.