Pinacidil (hydrate)

Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively. It completely relaxes coronary artery rings preconstricted with serotonin (Cay-14332, IC50 = 1.26 µM). Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.Formal Name: N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-guanidine, monohydrate. CAS Number: 85371-64-8. Molecular Formula: C13H19N5 . H2O. Formula Weight: 263.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml. SMILES: CC(C)(C)C(C)N/C(NC#N)=N/C1=CC=NC=C1.O. InChi Code: InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11,/h5-8,10H,1-4H3,(H2,15,16,17,18),1H2. InChi Key: AFJCNBBHEVLGCZ-UHFFFAOYSA-N.