Pimonidazole

Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.Formal Name: alpha-[(2-nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol. CAS Number: 70132-50-2. Synonyms: NSC 380540, Ro 03-8799. Molecular Formula: C11H18N4O3. Formula Weight: 254.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 0.15 mg/ml. lambdamax: 202, 316 nm. SMILES: OC(CN1CCCCC1)CN2C([N+]([O-])=O)=NC=C2. InChi Code: InChI=1S/C11H18N4O3/c16-10(8-13-5-2-1-3-6-13)9-14-7-4-12-11(14)15(17)18/h4,7,10,16H,1-3,5-6,8-9H2. InChi Key: WVWOOAYQYLJEFD-UHFFFAOYSA-N.