Pifithrin-alpha

Pifithrin-alpha is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 µM and in human umbilical vein endothelial cells at 30 µM. Pifithrin-alpha can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.Formal Name: 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide. CAS Number: 63208-82-2. Synonyms: PFT-alpha. Molecular Formula: C16H18N2OS . HBr. Formula Weight: 367.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 259 nm. SMILES: N=C(S1)N(CC(C2=CC=C(C)C=C2)=O)C3=C1CCCC3.Br. InChi Code: InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17,/h6-9,17H,2-5,10H2,1H3,1H. InChi Key: HAGVCKULCLQGRF-UHFFFAOYSA-N.