Piclidenoson

Piclidenoson is an adenosine A3 receptor agonist (Ki = 1.7 nM). It is selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively). In vivo, piclidenoson (100 µg/kg) reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion, an effect that can be reversed by the adenosine receptor antagonist 8-p-sulfophenyl theophylline. It reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and decreases the number of lung metastases in a model of metastatic murine melanoma. Piclidenoson (1 and 3 mg/kg) also reduces colonic inflammatory cell infiltration and damage in a mouse model of colitis induced by dextran sulfate (DSS, Cay-23250) and in IL-10-/- mice.Formal Name: 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-beta-D-ribofuranuronamide. CAS Number: 152918-18-8. Synonyms: CF-101, IB-MECA. Molecular Formula: C18H19IN6O4. Formula Weight: 510.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2mg/mL, DMSO: 2mg/mL, DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL. lambdamax: 268 nm. SMILES: [H][C@]1(O[C@H](C(NC)=O)[C@@H](O)[C@H]1O)N2C=NC3=C(NCC4=CC=CC(I)=C4)N=CN=C32. InChi Code: InChI=1S/C18H19IN6O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-3-2-4-10(19)5-9/h2-5,7-8,12-14,18,26-27H,6H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/m0/s1. InChi Key: HUJXGQILHAUCCV-MOROJQBDSA-N.