Phenytoin-d10

Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin (Cay-24037) by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin (Cay-23889). Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices (EC50s = 42.8 and 33.5 µM, respectively). It protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 10 mg/kg). Formulations containing phenytoin have been used in the treatment of tonic-clonic seizures and status epilepticus.Formal Name: 5,5-di(phenyl-d5)-2,4-imidazolidinedione. CAS Number: 65854-97-9. Synonyms: 5,5-Diphenylhydantoin-d10. Molecular Formula: C15H2D10N2O2. Formula Weight: 262.3. Purity: >99% deuterated forms (d1-d10). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC(N1)=O. InChi Code: InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)/i1D,2D,3D,4D,5D,6D,7D,8D,9D,10D. InChi Key: CXOFVDLJLONNDW-LHNTUAQVSA-N.