Phenamil (methanesulfonate)

Phenamil is an inhibitor of transient receptor potential polycystin-L (TRPP3, IC50 = 140 nM) and a derivative of amiloride (Cay-14409). It also inhibits the epithelial sodium channel (ENaC, IC50 = 400 nM). Phenamil decreases basal short-circuit currents in human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively. It inhibits potassium chloride-induced contractions in isolated rat endothelium-denuded aortic rings (EC50 = 6.76 µM) and increases contractile force in isolated rat right ventricular papillary muscles (EC50 = 16.98 µM). Phenamil (15 and 30 mg/kg per day) reduces pulmonary artery medial wall thickness and decreases right ventricular peak pressure in a rat model of chronic hypoxia-induced pulmonary hypertension.Formal Name: 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-2-pyrazinecarboxamide, monomethanesulfonate. CAS Number: 1161-94-0. Molecular Formula: C12H12ClN7O . CH3SO3H. Formula Weight: 401.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 289, 362 nm. SMILES: ClC1=C(N)N=C(N)C(C(NC(NC2=CC=CC=C2)=N)=O)=N1.CS(=O)(O)=O. InChi Code: InChI=1S/C12H12ClN7O.CH4O3S/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6,1-5(2,3)4/h1-5H,(H4,14,15,19)(H3,16,17,20,21),1H3,(H,2,3,4). InChi Key: MHPIZTURFVSLTJ-UHFFFAOYSA-N.