PF-06928215

PF-06928215 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 4.9 µM in a fluorescence polarization assay).Formal Name: (1R,2S)-2-[[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)carbonyl]amino]-cyclohexanecarboxylic acid. CAS Number: 2378173-15-8. Molecular Formula: C20H20N4O4. Formula Weight: 380.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml. SMILES: OC([C@H](CCCC1)[C@H]1NC(C2=C3N(N=C2)C(O)=CC(C4=CC=CC=C4)=N3)=O)=O. InChi Code: InChI=1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,25H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1. InChi Key: PHGTYMRDHDEHLI-HIFRSBDPSA-N.