PF-06826647

PF-06826647 is an inhibitor of tyrosine kinase 2 (TYK2, IC50 = 15 nM). It is selective for TYK2 over JAK1, JAK2, and JAK3 (IC50s = 383, 74, and >10,000 nM, respectively). PF-06826647 inhibits IL-12-induced phosphorylation of STAT4 in isolated human whole blood (IC50 = 14 nM). In vivo, PF-06826647 (3-30 mg/kg, p.o.) reduces ear edema in a mouse model of skin inflammation induced by the toll-like receptor 7 (TLR7) agonist imiquimod (Cay-14956).Formal Name: trans-3-cyano-1-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl]-cyclobutaneacetonitrile. CAS Number: 2127109-84-4. Synonyms: Ropsacitinib, TYK2-IN-8, TYK2 Inhibitor 8. Molecular Formula: C20H17N9. Formula Weight: 383.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: N#CC[C@]1(N2C=C(C3=NC(C4=CN(C)N=C4)=CN5C3=CC=N5)C=N2)C[C@@H](C1)C#N. InChi Code: InChI=1S/C20H17N9/c1-27-11-15(9-24-27)17-13-28-18(2-5-23-28)19(26-17)16-10-25-29(12-16)20(3-4-21)6-14(7-20)8-22/h2,5,9-14H,3,6-7H2,1H3/t14-,20-. InChi Key: XPLZTJWZDBFWDE-OYOVHJISSA-N.