PF-06649751

PF-06649751 is a dopamine D1 and D5 receptor partial agonist. It increases locomotor activity and reduces a global parkinsonian disability score in a macaque model of Parkinson's disease induced by MPTP when administered at a dose of 0.04 mg/kg.Formal Name: 1,5-dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione. CAS Number: 1643489-24-0. Synonyms: CVL-751. Molecular Formula: C19H16F3N3O3. Formula Weight: 391.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml, Ethanol: 2 mg/ml. lambdamax: 273 nm. SMILES: O=C1NC(N(C)C(C2=C(C)C=C(OC3=NC=CC=C3C(F)(F)F)C=C2)=C1C)=O. InChi Code: InChI=1S/C19H16F3N3O3/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27). InChi Key: AKQXQLUNFKDZBN-UHFFFAOYSA-N.