PF-00489791

PF-00489791 is an inhibitor of phosphodiesterase 5A (PDE5A, IC50 = 1.9 nM). It does not cross the blood-brain barrier in rats. PF-00489791 (10 mg/kg) improves motor scores in a rat model of stroke induced by middle cerebral artery occlusion (MCAO).Formal Name: 1-(2-ethoxyethyl)-5-(ethylmethylamino)-7-[(4-methyl-2-pyridinyl)amino]-N-(methylsulfonyl)-1H-pyrazolo[4,3-d]pyrimidine-3-carboxamide. CAS Number: 853003-48-2. Synonyms: PF-489791, UK 489791. Molecular Formula: C20H28N8O4S. Formula Weight: 476.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMF: Slightly soluble, DMSO: Slightly soluble, Water: Soluble. SMILES: O=C(C(C1=NC(N(C)CC)=NC(NC2=CC(C)=CC=N2)=C13)=NN3CCOCC)N[S](C)(=O)=O. InChi Code: InChI=1S/C20H28N8O4S/c1-6-27(4)20-23-15-16(19(29)26-33(5,30)31)25-28(10-11-32-7-2)17(15)18(24-20)22-14-12-13(3)8-9-21-14/h8-9,12H,6-7,10-11H2,1-5H3,(H,26,29)(H,21,22,23,24). InChi Key: ZUHZNKJIJDAJFD-UHFFFAOYSA-N.