Perlapine

Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADDs) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing. Perlapine displays >10,000-fold selectivity for hM3Dq over hM3.Formal Name: 6-(4-methyl-1-piperazinyl)-11H-dibenz[b,e]azepine. CAS Number: 1977-11-3. Synonyms: 6-(4-Methyl-1-piperazinyl)morphanthridine, NSC 291840. Molecular Formula: C19H21N3. Formula Weight: 291.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 250, 306 nm. SMILES: CN(CC1)CCN1C2=NC(C=CC=C3)=C3CC4=C2C=CC=C4. InChi Code: InChI=1S/C19H21N3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9H,10-14H2,1H3. InChi Key: PWRPUAKXMQAFCJ-UHFFFAOYSA-N.