Penfluridol

Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM). It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively). Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Cay-16094) in cynomolgus monkeys. It also inhibits proliferation of triple-negative breast cancer cells (TNBCs, IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin alpha6 and beta4. Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.Formal Name: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol. CAS Number: 26864-56-2. Synonyms: R-16341. Molecular Formula: C28H27ClF5NO. Formula Weight: 524.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 220, 266, 272 nm. SMILES: FC1=CC=C(C(CCCN2CCC(C3=CC=C(Cl)C(C(F)(F)F)=C3)(O)CC2)C4=CC=C(F)C=C4)C=C1. InChi Code: InChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2. InChi Key: MDLAAYDRRZXJIF-UHFFFAOYSA-N.