PDM 2

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 µM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.Formal Name: 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene. CAS Number: 688348-25-6. Molecular Formula: C14H9Cl3. Formula Weight: 283.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 2 mg/ml. lambdamax: 214, 302, 313 nm. SMILES: Clc1ccc(cc1)\C=C/c1cc(Cl)cc(Cl)c1. InChi Code: InChI=1S/C14H9Cl3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9H/b2-1+. InChi Key: JMYNPQVCVQVODQ-OWOJBTEDSA-N.