PDE7 inhibitor S14

Description: PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway. Target: Others. Smiles: O=C1N(C(=S)NC2=CC=CC=C12)C1=CC=CC=C1. References: Bartolome F, de la Cueva M, Pascual C, Antequera D, Fernandez T, Gil C, Martinez A, Carro E. Amyloid beta-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimers Res Ther. 2018 Feb 20,10(1):24. doi: 10.1186/s13195-018-0352-4. PubMed PMID: 29458418, PubMed Central PMCID: PMC5819290.