PD 98059

PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAP2K1. It inhibits Raf activation of MAP2K2 with an IC50 value of 50 µM. PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).Formal Name: 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 167869-21-8. Synonyms: NSC 679828. Molecular Formula: C16H13NO3. Formula Weight: 267.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:9): 0.25 mg/ml, Ethanol: .5 mg/ml. lambdamax: 239, 300, 375 nm. SMILES: COc1cccc(c2cc(=O)c3ccccc3o2)c1N. InChi Code: InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3. InChi Key: QFWCYNPOPKQOKV-UHFFFAOYSA-N.