PD 174265

Description: PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM. Target: EGFR. Smiles: CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1. References: Fry DW, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29,95(20):12022-7.