PD-1/PD-L1 Inhibitor N11

PD-1/PD-L1 inhibitor N11 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1, IC50 = 6.3 nM). It increases T cell proliferation in a PD-L1-overexpressing CT26 colon cancer cell and T cell co-culture when used at a concentration of 20 nM. PD-1/PD-L1 inhibitor N11 (20 and 80 nM) promotes T cell infiltration into an in vitro PD-L1-overexpressing murine Lewis lung carcinoma tumor matrix. In vivo, PD-1/PD-L1 inhibitor N11 (20 mg/kg) reduces tumor growth and promotes CD8+ and CD4+ T cell tumor infiltration in a PD-L1-overexpressing murine Lewis lung carcinoma model.Formal Name: 2-methyl-2-(((4-(4-phenylindolin-1-yl)pyrido[3,2-d]pyrimidin-7-yl)methyl)amino)propan-1-ol. Synonyms: PD-1/PD-L1 Interaction Inhibitor, Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor N11. Molecular Formula: C26H27N5O. Formula Weight: 425.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: OCC(C)(C)NCC(C=N1)=CC2=C1C(N3CCC4=C3C=CC=C4C5=CC=CC=C5)=NC=N2. InChi Code: InChI=1S/C26H27N5O/c1-26(2,16-32)30-15-18-13-22-24(27-14-18)25(29-17-28-22)31-12-11-21-20(9-6-10-23(21)31)19-7-4-3-5-8-19/h3-10,13-14,17,30,32H,11-12,15-16H2,1-2H3. InChi Key: CZQOYRCWBPWJJP-UHFFFAOYSA-N.